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Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 248-252 doi: 10.1007/s11684-007-0047-x

Abstract: The aim of this study was to investigate the role of p38 mitogen-activated protein kinase (MAPK) in cellWestern blot was performed to detect the phosphorylation of p38 in NIH3T3 cells treated with PDGF.the migration of NIH3T3 cells and the influence of deficiency on this process in a gene knockout (p38Furthermore, the PDGF-induced cell migration was significantly blocked in gene knockout (p38) mouseembryonic fibroblasts (MEFs) (〈0.001) as compared with the wild type cells (p38). p38 MAPK plays an important

Keywords： control     stimulation     mitogen-activated     growth factor     process    

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Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 232-237 doi: 10.1007/s11705-012-1286-1

Abstract: Three groups of animals were examined respectively for inoculation of inhibitor of p38 MAPK (mitogenactivated protein kinase) SB 203580 and JNK inhibitor SP 600125, and a control.Light microscopy, immunohistochemistry, and tensometry revealed that the inhibition of p38 or JNK cascadesSB203580 inhibits the expression of p38, c-Jun and c-Fos.When we have used the JNK blocker, the expression of c-Fos and c-Jun decreased, but the expression of p38

Keywords： connective tissue     mitogen activated protein kinase (MAPK)     p38     JNK    

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Effect of PRAK gene knockout on the proliferation of mouse embryonic fibroblasts

Xiaowei GONG MD, PhD, Xiaoyan MING MD, Xu WANG MM, Daan WANG MD, Peng DENG MM, Yong JIANG MD, PhD, Aihua LIU MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 379-383 doi: 10.1007/s11684-009-0073-y

Abstract: p38 regulated/activated protein kinase (PRAK) plays a key role in cell senescence and tumor suppression

Keywords： p38 regulated/activated protein kinase     gene knockout     cell cycle     cell proliferation    

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Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 46-53 doi: 10.1007/s11684-010-0010-0

Abstract: Mitogen-activated protein kinase (MAPK) signaling pathway, one of the most important signaling pathwaysSo far, inhibitors specifically against each subfamilies of MAP kinase have been developed, while moreMost of the kinase inhibitors exert their functions in an ATP-competitive way or a non-ATP-competitiveinhibitors and their therapeutic roles in the treatment of diseases are helpful for the illumination of MAP kinase

Keywords： mitogen-activated protein kinase     drug target     inhibitor     signal transduction     disease    

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Mechanisms of insulin resistance in obesity

Jianping Ye

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 14-24 doi: 10.1007/s11684-013-0262-6

Abstract: <p>Obesity increases the risk for type 2 diabetes through induction of insulin resistance.The energy surplus signal is mediated by ATP and sensed by adenosine monophosphate-activated proteinkinase (AMPK) signaling pathway.p>

Keywords： energy expenditure     inflammation     lipotoxicity     mitochondria     hyperinsulinemia     adenosine monophosphate-activatedprotein kinase (AMPK)    

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The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract: <p>Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family.p>

Keywords： protein kinase C ?     signal transduction     neurogenic disease    

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PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 399-403 doi: 10.1007/s11684-014-0380-9

Abstract: <p>We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinase1 (PAK1), a member of a serine/threonine protein kinase family.that provides a mechanism for specifically affecting cardiac cellular processes in which regulation of proteinphosphorylation states by protein phosphatase 2A (PP2A) predominates.p>

Keywords： p21-activated kinase 1 (PAK1)     heart    

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Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway and

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 534-548 doi: 10.1007/s11684-022-0953-y

Abstract: phosphoproteomic analysis and RNA-seq revealed that MenSCs improved AIH, mainly by apoptosis and c-Jun N-terminal kinase/mitogen-activated protein signaling pathways.Apoptosis analysis demonstrated that the protein expression of cleaved caspase 3 was increased by Con

Keywords： AIH)     concanavalin A (Con A)     human menstrual blood-derived stem cells (MenSCs)     apoptosis     mitogen-activatedprotein kinase (MAPK)    

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Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: The aim of this study is to investigate the effect of tyrosine kinase Src on Tyrosine 307(Y307) phosphorylation, protein phosphatase 2A (PP2A) activity, and on tau phosphorylation.siRNA was transfected into cultured mouse neuroblastoma N2a cells to inhibit the expression of Src proteinTwelve hours after siRNA transfection, the protein level of Src was dramatically decreased, with decreasedHowever, the total PP2A protein level was also decreased, together with a decreased PP2A activity.

Keywords： hyperphosphorylation     PP2A activity     cellular regulation     siRNA     siRNA transfection    

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RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 143-155 doi: 10.1007/s11684-022-0929-y

Abstract: RGS16 belongs to the regulator of G-protein signalling (RGS) protein family, which plays an importantHowever, whether RGS16 can promote the progression of glioma and whether it is regulated by miR let-7c-5p are still unknown.Moreover, RGS16 was validated as a direct target gene of miR let-7c-5p.miR let-7c-5p had the opposite effect.

Keywords： RGS16     let-7c-5p     glioma     proliferation     migration    

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Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters

Fen LAN, Shengdao XIONG, Weining XIONG, Guopeng XU, Xiaoxia LU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 41-44 doi: 10.1007/s11684-009-0009-6

Abstract: This study aims to research the expression of spleen tyrosine kinase (Syk) in non-small cell lung cancer(NSCLC) and the relationship between Syk and clinicopathologic factors and p53.Immunohistochemistry was applied to detect the expression of Syk and p53 protein in 39 cases of NSCLCThe Syk expression was positively correlated withthe p53 expression in NSCLC specimens ( = 0.025).

Keywords： Syk kinase     carcinoma     non-small-cell lung     tumor suppressor protein p53    

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Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial

Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 431-436 doi: 10.1007/s11684-009-0088-4

Abstract: The effects of tanshinone II A on cell signal transduction system protein kinase B in rats with myocardialdiameter (MFD) was examined by Hematoxylin-Eosin (HE) staining, and the contents of phosphorylated proteinkinase B (p-Akt) and p-Gsk3β in myocardium were assayed by Western blot., and p-Gsk3β were also increased in other groups., and p-Gsk3β were also decreased in all treatment groups.

Keywords： tanshinone II A     myocardial hypertrophy     rat     protein kinase B     abdominal aorta coarctation    

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Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 200-206 doi: 10.1007/s11684-007-0038-y

Abstract: Elevated plasma levels of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic of type 2 diabetes mellitus. In this study, we investigated the effects of two fatty acids, palmitate (PA) and arach

Keywords： palmitate     characteristic     study     plasma     resistance    

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Fate of proteins of waste activated sludge during thermal alkali pretreatment in terms of sludge protein

Xiaoli Song, Zhenghua Shi, Xiufen Li, Xinhua Wang, Yueping Ren

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 2, doi: 10.1007/s11783-019-1114-7

Abstract: <p> <p>Maillard reaction between reducing sugars and amides happened duringp> <p>Over 90 min of TAH at the optimal condition,p> <p>15.84% soluble proteins broke down to materialsp>p>

Keywords： Sludge flocs     Microbial cells     Hydrolysate     Protein breakdown     Melanoidin    

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Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: The Fc fragment of the IgG-binding protein (FCGBP) was identified as the most promising indicator ofAmong them, a mechanistic target of rapamycin kinase (mTOR) inhibitor, which is a macrolide compound

Keywords： severe Mycoplasma pneumoniae pneumonia     children     proteomics     Fc fragment of the IgG-binding protein     mechanistic target of rapamycin kinase inhibitor    

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Title Author Date Type Operation

Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

Journal Article

Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Journal Article

Effect of PRAK gene knockout on the proliferation of mouse embryonic fibroblasts

Xiaowei GONG MD, PhD, Xiaoyan MING MD, Xu WANG MM, Daan WANG MD, Peng DENG MM, Yong JIANG MD, PhD, Aihua LIU MD, PhD,

Journal Article

Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Journal Article

Mechanisms of insulin resistance in obesity

Jianping Ye

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article

PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Journal Article

Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway and

Journal Article

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Journal Article

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Journal Article

Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters

Fen LAN, Shengdao XIONG, Weining XIONG, Guopeng XU, Xiaoxia LU

Journal Article

Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial

Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,

Journal Article

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Journal Article

Fate of proteins of waste activated sludge during thermal alkali pretreatment in terms of sludge protein

Xiaoli Song, Zhenghua Shi, Xiufen Li, Xinhua Wang, Yueping Ren

Journal Article

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Journal Article